The 1st lesson of "The Anatomy of DJ’ing" introduces the key components of a turntable. It provides detailed instructions on setting up a turntable, including leveling, adjusting the tonearm height, balancing the counterweight, and setting the anti-skating force to prevent needle skipping. The lesson also covers connecting a turntable to a mixer, explaining the difference between line and phono inputs, and offering tips for minimizing vibrations for optimal sound quality.